Physician-Scientist

Mohamed Khair Ibraheem

MD, MS
Physician-Scientist
Mayo Clinic Arizona · Scottsdale, Arizona
Critical Care · Clinical AI · Acute Illness · Transplantation

In critical care, a prediction model can only learn the outcomes someone bothered to look for. I study what happens to clinical AI when the label itself depends on who got tested.

Professional portrait of Mohamed Khair Ibraheem, MD, MS
Mohamed Khair Ibraheem, MD, MS · Physician-Scientist
Profile

Clinical questions before algorithms.

I am a physician-scientist focused on critical care and clinical artificial intelligence. My research examines how AI can support high-consequence decisions in acute illness, particularly when the data used to train a model are shaped by who gets tested, what clinicians choose to measure, and which outcomes become visible in the medical record.

I study outcome ascertainment, selective testing, missing clinical information, interpretability, and treatment decisions: factors that determine whether a model is learning clinically meaningful biology or simply reproducing patterns of observation and care.

Critical care and acute illness are the central clinical setting for this work, including sepsis, severe infection, and acute illness-associated cardiovascular outcomes. Collaborative work in pulmonary medicine, kidney disease, transplantation, and surgery extends these questions into other high-risk clinical populations.

Are our models learning the patient's biology, or the way the healthcare system chose to observe the patient?
Research Program

What I study

My research is organized around the reliability of clinical evidence when observation, testing, treatment, and documentation are themselves selective.

Critical Care + AI

Clinical AI in critical care & acute illness

My primary research focus is the development, evaluation, and critical appraisal of clinical AI for high-acuity care. Work in sepsis and severe infection examines model discrimination, interpretability, bias, generalizability, and the gap between retrospective performance and bedside clinical utility.

Label Bias

Outcome ascertainment & selective testing

A prediction model can only learn the outcomes someone bothered to look for. I study what happens when clinical AI is trained on labels shaped by surveillance intensity, selective testing, missing outcomes, and clinical workflow rather than biology alone.

Decision Science

From risk prediction to treatment decisions

Risk prediction asks who is likely to have an outcome. A more consequential question is which patient is likely to benefit from a specific intervention. This direction connects clinical AI with causal inference, treatment-effect heterogeneity, and individualized decision support in acute care.

Critical Care Outcomes

Acute illness, sepsis & cardiovascular outcomes

Clinical outcomes research in sepsis, severe infection, and acute illness-associated atrial fibrillation provides real-world settings for studying prediction, treatment selection, competing risks, and clinically actionable decision support.

Related Domains

Transplantation, kidney disease & surgery

Selected collaborative work in transplantation, nephrology, pulmonary medicine, and surgery extends the same methodological questions into complex populations where surveillance, selection, and longitudinal outcomes are especially important.

Scientific Communication

Research in scientific exchange

Recent scientific work includes multicenter outcomes research in acute illness-associated atrial fibrillation presented at Heart Rhythm 2026, alongside research in clinical AI, transplantation, kidney disease, and acute-care medicine.

Heart Rhythm 2026

Selected Work

Publications & scientific contributions

Selected work reflecting the clinical and methodological themes of the research program.

2025

Peer-reviewed clinical work in pulmonary and systemic disease

Respiratory and multidisciplinary clinical literature

2016

Surgical and Non-Surgical Management of Intussusceptions

Book chapter · Contemporary General Surgery · Ain Shams University

Background

Clinical and academic foundation

Surgical training and multidisciplinary clinical research provide the clinical context for a program focused on high-consequence decisions rather than algorithms in isolation.

Mayo Clinic Arizona

Clinical research

Research collaboration across critical care, pulmonary medicine, nephrology, transplantation, acute illness outcomes, and clinical AI.

Ain Shams University

MS · General Surgery

Graduate surgical training and scholarship, including work on surgical and non-surgical management of intussusception.

Clinical Foundation

General Surgery

Training and practice across general, gastrointestinal, trauma, emergency, and perioperative surgical care.

Contact

Academic collaboration & scientific correspondence

For research collaboration, scholarly correspondence, and scientific inquiries.